3-Carboxyphenylboronic acid, identified by CAS 25487-66-5, is an aromatic boronic acid that also contains a carboxylic acid group. I commonly describe it as a bifunctional building block for organic synthesis because its boronic acid group can participate in cross-coupling chemistry while its carboxyl group provides an additional site for derivatization. The commonly reported molecular formula is C7H7BO4, with a molecular weight of approximately 165.94 g/mol. For B2B buyers, the most important questions are usually identity, assay, impurity profile, packaging, documentation, and whether the material matches the intended reaction or development stage.
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3-Carboxyphenylboronic acid is an organoboron compound in which a boronic acid functionality and a carboxylic acid functionality are attached to a benzene ring. The “3-carboxy” description indicates that the carboxyl group is positioned meta to the boronic acid substituent on the aromatic ring. This arrangement gives the molecule two chemically useful handles that can be used sequentially or selectively during synthesis.
The substance is often discussed under related naming conventions such as 3-boronobenzoic acid, although buyers should use the CAS number as the primary identity reference when comparing supplier documents. The approximate molecular weight of 165.94 g/mol is useful for reaction calculations and procurement records. I still advise customers to verify the molecular formula and molecular weight shown on the current specification sheet or certificate of analysis supplied for the individual lot.
The boronic acid group is valued in synthetic chemistry because aryl boronic acids are commonly used as coupling partners in Suzuki–Miyaura reactions. Under suitable reaction conditions, the aryl group can be transferred to an aryl or heteroaryl halide, forming a new carbon–carbon bond. The carboxylic acid group can offer a separate transformation site, which may be useful for preparing amides, esters, activated acids, or other functionalized intermediates.
This dual reactivity does not mean that every reaction will proceed under the same conditions. The choice of base, solvent, catalyst, temperature, reaction time, and protection strategy can affect conversion and selectivity. I therefore treat 3-Carboxyphenylboronic acid as a versatile starting material rather than a universal drop-in reagent.
Commercial samples are generally supplied as a solid, but the exact appearance and physical condition can vary with manufacturing process, particle size, moisture exposure, and packaging. Boronic acids may be sensitive to storage conditions, and the carboxylic acid group can influence polarity and solubility in different solvents. A buyer should consult the supplier’s SDS and handling instructions instead of relying only on a catalog description.
Solubility should be evaluated in the actual reaction solvent because a material that is only sparingly soluble in one medium may behave differently in a mixed solvent or in the presence of base. I recommend a small-scale solubility check before committing to process-scale use. This practical test can help identify whether pre-dissolution, controlled addition, heating, or an alternative solvent system is needed.
In pharmaceutical research, 3-Carboxyphenylboronic acid can serve as an intermediate for introducing a substituted aromatic unit into a target molecule. The boronic acid functionality may be used to connect the aromatic ring with another fragment through carbon–carbon coupling. After that step, the carboxylic acid can be converted into an amide or ester, allowing medicinal chemists to explore structure–activity relationships.
Its value is especially relevant when a synthesis requires two independent functional handles on the same aromatic building block. However, suitability depends on the target structure, route sequence, protection requirements, and impurity tolerance. I encourage development teams to evaluate reaction compatibility using their own substrate and process conditions.
The compound may also be considered for the preparation of ligands, functional aromatic intermediates, fluorescent or conjugated structures, and research materials containing boron-derived or carboxyl-derived functionality. These uses are application-dependent and may remain at laboratory or development scale. The appropriate grade, packaging size, and documentation can therefore differ significantly between research procurement and manufacturing procurement.
Suppliers may offer different package sizes, assay targets, and documentation levels for the same CAS number. A small research package may be appropriate for route screening, while a larger technical or production-oriented order may require tighter control of water, residual solvents, inorganic impurities, and lot-to-lot consistency. I recommend defining the required specification before comparing prices.
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| Buyer Requirement | What to Confirm | Why It Matters |
|---|---|---|
| Identity | CAS 25487-66-5, name, formula, and analytical identification | Prevents substitution with a positional isomer or differently named compound |
| Purity | Assay method, stated purity target, and impurity profile | Supports reaction reproducibility and downstream process evaluation |
| Physical condition | Appearance, particle form, packaging, and storage guidance | Helps with weighing, transfer, dissolution, and handling planning |
| Documentation | COA, SDS, batch information, and export documents where required | Supports quality review, safety assessment, and internal approval |
For chemical calculations, the approximate molecular weight is 165.94 g/mol, but the value used in a controlled process should match the approved specification and calculation procedure. Buyers should also confirm whether the reported assay is measured by HPLC, titration, NMR, or another method, because different methods may describe different aspects of material quality. I avoid treating a single purity number as a complete quality assessment.
For early discovery work, a buyer may prioritize rapid availability, small quantities, and basic identity documentation. For process development, the focus generally shifts toward repeatability, impurity characterization, stable packaging, and technical communication. For commercial planning, buyers should additionally discuss forecast volume, manufacturing capacity, change-control expectations, and lead-time visibility.
I recommend requesting a current specification sheet and representative COA before approving a supplier. The review should include assay, key impurities, water content if relevant to the reaction, appearance, storage conditions, and retest or shelf-life information when provided. It is also practical to confirm whether the quoted lead time is based on ready stock, production scheduling, or custom preparation.
Quantity planning should be based on actual project consumption rather than only the lowest unit price. For example, a 25 kg requirement may involve different production, packaging, and shipping considerations from a 100 g laboratory order. Lead time can also vary by quantity, destination, documentation requirements, and whether the requested specification is standard or customized.
One common mistake is ordering by chemical name alone without checking the CAS number and positional isomer. Another is assuming that a high assay automatically guarantees performance in every coupling or derivatization reaction. In practice, solvent compatibility, catalyst system, substrate structure, moisture, and impurity sensitivity can all influence results.
A further mistake is postponing documentation review until after shipment. I suggest confirming the required documents, labeling format, packaging configuration, and import information during quotation. This approach reduces avoidable delays between purchasing, quality, safety, and receiving teams.
At Maison Chemical, I approach 3-Carboxyphenylboronic acid CAS 25487-66-5 as a technical sourcing requirement, not simply a catalog item. We can discuss intended use, target quantity, specification expectations, packaging, and destination requirements before quotation. Our role is to help buyers compare the material against their synthesis, quality, and supply-chain needs.
For qualified inquiries, I recommend providing the expected annual or project quantity, preferred assay target, application stage, delivery location, and required documents. This information helps us assess the appropriate supply option and provide a more relevant quotation. Where a buyer needs additional technical clarification, we can coordinate available product information and batch documentation for internal evaluation.
3-Carboxyphenylboronic acid CAS 25487-66-5 is a bifunctional aromatic building block combining a boronic acid group with a carboxylic acid group. Its principal value comes from the ability to support carbon–carbon coupling and further carboxyl-derived transformations within a synthetic route. It may be suitable for pharmaceutical intermediates, medicinal chemistry, specialty synthesis, and selected materials research, subject to reaction-specific evaluation.
My recommended next step is to confirm identity, molecular weight, assay method, impurity requirements, packaging, and documentation with the supplier before purchase. Send Maison Chemical your target quantity, application, destination, and specification requirements so we can help assess availability and prepare a B2B quotation. A structured pre-purchase review gives your team a clearer basis for evaluating technical fit, delivery risk, and total sourcing suitability.
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