1-Methyl-4-pyrazole boronic acid pinacol ester, identified by CAS 761446-44-0, is a boronic ester building block used primarily in organic synthesis and pharmaceutical intermediate research. Its most important function is to provide a pyrazole-containing partner for palladium-catalyzed cross-coupling, especially Suzuki–Miyaura reactions. In practical purchasing, I recommend confirming the identity, assay, water content, analytical data, packaging, storage instructions, and batch availability before placing an order.
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At Maison Chemical, I support buyers who need this intermediate for route development, process research, medicinal chemistry, or commercial sourcing evaluation. The product should be assessed not only by price, but also by consistency between batches, documentation quality, logistics requirements, and the supplier’s ability to support repeat orders.
This guide is intended for pharmaceutical and fine chemical companies, research laboratories, contract development organizations, procurement teams, and distributors evaluating CAS 761446-44-0. It is useful when a project requires a methyl-substituted pyrazole fragment that can be introduced through a boronic ester coupling reaction. It can also help buyers prepare a more complete request for quotation and technical information.
I have written this overview for users who need a practical sourcing framework rather than a purely theoretical description. The exact suitability of this compound depends on the reaction route, substrate, catalyst system, scale, and required quality standard. Buyers should therefore use the information below as a screening guide and confirm product-specific details with the supplier.
1-Methyl-4-pyrazole boronic acid pinacol ester is an organoboron compound containing a 1-methylpyrazole ring and a pinacol-protected boronic ester group. The boronic ester is designed to participate in carbon–carbon bond-forming chemistry under suitable reaction conditions. The pyrazole ring remains part of the final molecular structure and may contribute useful polarity and heteroatom functionality to a target intermediate.
The commonly referenced product identity is CAS 761446-44-0. Its molecular formula is generally listed as C10H15BN2O2, with a molecular weight of approximately 206.05 g/mol. The formula contains 10 carbon atoms, 15 hydrogen atoms, 1 boron atom, 2 nitrogen atoms, and 2 oxygen atoms; buyers should still compare these details with the supplier’s current certificate of analysis and specification sheet.
| Item | Buyer-Relevant Information |
|---|---|
| Product name | 1-Methyl-4-pyrazole boronic acid pinacol ester |
| CAS number | 761446-44-0 |
| Molecular formula | C10H15BN2O2 |
| Approximate molecular weight | 206.05 g/mol |
| Functional group | Pinacol boronic ester connected to a 1-methylpyrazole ring |
| Typical quality documents | Certificate of analysis, analytical spectrum or chromatogram, specification sheet, and safety documentation where applicable |
Appearance, melting behavior, purity, water content, residual solvents, and stability should not be assumed from the chemical name alone. These values can vary according to manufacturing process, drying conditions, analytical method, and packaging history. I recommend requesting the current batch-specific data rather than relying only on a general catalogue description.
The principal application of this compound is as a boron-containing coupling partner in synthetic chemistry. Under an appropriate catalytic system, the boronic ester may react with an aryl or heteroaryl halide to form a new carbon–carbon bond. This approach can help introduce a 1-methylpyrazolyl group into a more complex intermediate.
Reaction performance depends on the electrophile, catalyst, ligand, base, solvent, temperature, reaction time, and sensitivity of the substrate. I do not recommend treating the compound as universally compatible with every coupling protocol. A small-scale feasibility study is normally appropriate before process quantities are ordered.
Pyrazole-containing structures appear in many areas of medicinal chemistry because the ring can be incorporated into molecules with varied hydrogen-bonding and electronic properties. CAS 761446-44-0 may therefore be considered during the synthesis of research compounds and pharmaceutical intermediates that require a methylated pyrazole fragment.
Its use in a particular active pharmaceutical ingredient route must be evaluated by the project’s chemists and regulatory team. The presence of a boronic ester does not by itself establish suitability for a regulated manufacturing process. Route-specific impurity control, residual metal assessment, elemental analysis, and process validation may be required at later stages.
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First, identify whether the material is needed for analytical research, milligram-level screening, gram-scale route development, or larger process work. Small projects may prioritize fast delivery and flexible pack sizes, while process development teams usually need stronger control of batch records, impurity profiles, and repeat availability. I recommend communicating the expected first order and approximate annual demand separately.
At minimum, request the product name, CAS number, molecular formula, molecular weight, assay method, purity result, water content where relevant, residual solvent information, and analytical identification. Depending on the project, buyers may also request HPLC, GC, NMR, LC-MS, or other appropriate data. The supplier should clarify whether the reported purity is area percentage, assay by a validated method, or another measurement.
Boronic esters can require protection from moisture and unsuitable storage conditions. The correct storage temperature must be based on product-specific stability information and the supplier’s label or technical documentation; buyers should not automatically impose a 2–8 °C requirement without confirmation. Packaging should also be selected according to order size, expected opening frequency, transportation duration, and the need to reduce exposure to air or humidity.
Price should be compared together with minimum order quantity, available stock, production lead time, shipping method, export documentation, and payment terms. A low unit price may not be advantageous if the material requires an impractical minimum quantity or if documentation is incomplete. For repeat programs, I suggest asking whether the supplier can reserve a production slot or provide a realistic replenishment schedule.
One common mistake is requesting a quotation with only the product name and no quality requirement. This can lead to confusion over pack size, purity basis, analytical documentation, and whether the quotation covers a research-grade or process-oriented material. A better inquiry includes CAS 761446-44-0, required quantity, destination, target specification, packaging preference, and requested documents.
Another mistake is assuming that catalogue availability means continuous stock. Specialty intermediates may be supplied from existing inventory, made to order, or produced according to a campaign schedule. Buyers should ask whether the quoted batch is available now, how long dispatch may take, and whether the same specification can be maintained for future orders.
It is also important not to overlook moisture, residual solvents, and trace metal requirements. These factors can affect downstream reactions and purification, even when the headline purity appears acceptable. I recommend aligning the incoming-material specification with the actual needs of the synthetic route.
Maison Chemical supplies pharmaceutical intermediates and specialty chemicals for customers evaluating research and production requirements. For 1-Methyl-4-pyrazole boronic acid pinacol ester, I can help organize a quotation around quantity, specification, packaging, documentation, and delivery destination. Where product-specific information must be confirmed, I will treat it as a verification item rather than make an unsupported assumption.
For a more efficient response, please provide the required quantity, target purity, intended application, preferred packaging, destination country, and desired delivery date. If your project has limits for water, residual solvents, metals, or specific analytical methods, include them in the initial inquiry. This allows the supply option to be evaluated against your actual process rather than against price alone.
1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 is a useful boronic ester intermediate for introducing a 1-methylpyrazole fragment into more complex molecules. Its practical value depends on reaction compatibility, material quality, documentation, and supply reliability rather than on chemical identity alone. I recommend beginning with a clear technical specification and confirming the current batch information before purchase.
To move forward, send Maison Chemical your required quantity, target quality standard, packaging preference, destination, and desired lead time. We can then review the appropriate supply route and provide the relevant commercial and technical information for your project.
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