I use 2,4,6-trifluorophenylboronic acid, CAS 182482-25-3, primarily as a fluorinated aryl-boron building block for medicinal chemistry, pharmaceutical intermediate development, and palladium-catalyzed Suzuki–Miyaura coupling research. Its molecular formula is C6H4BF3O2, and its calculated molecular weight is approximately 175.90 g/mol. The molecule contains one boronic acid group and three fluorine atoms positioned at the 2, 4, and 6 positions of the aromatic ring. For purchasing, I recommend confirming identity, assay, water content, packaging, storage conditions, and batch-specific documentation before placing a commercial order.
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This guide is intended for procurement teams, process chemists, medicinal chemists, formulation researchers, and distributors sourcing 2,4,6-trifluorophenylboronic acid for laboratory or development use. It is also useful for buyers comparing custom synthesis, catalog supply, and larger-scale manufacturing options. I focus on the information that directly affects material selection, reaction planning, quality review, and supply continuity.
Because commercial specifications can differ between suppliers, I distinguish between generally established structural information and specifications that must be confirmed from a current certificate of analysis. A product listing alone is not sufficient for a regulated or scale-up project. Buyers should review the supplier’s specification sheet, SDS, analytical data, and packaging proposal before approval.
2,4,6-Trifluorophenylboronic acid is an arylboronic acid in which a boronic acid substituent is attached to a benzene ring containing fluorine atoms at the 2, 4, and 6 positions. The boronic acid group is the principal reactive handle, while the fluorinated aromatic ring provides a defined electronic and steric environment for synthetic design. Its CAS Registry Number is 182482-25-3.
The molecular formula contains 6 carbon atoms, 4 hydrogen atoms, 1 boron atom, 3 fluorine atoms, and 2 oxygen atoms. Based on standard atomic weights, the molecular weight is approximately 175.90 g/mol. PubChem is an appropriate public reference for checking compound identity, formula, molecular weight, synonyms, and structure; I recommend comparing any supplier record against the PubChem entry and the supplier’s own analytical documents.
Source: U.S. National Library of Medicine, PubChem, PubChem Compound Database. Always verify the specific compound record and current supplier documentation before use.
| Parameter | Reference information | Purchasing relevance |
|---|---|---|
| Product name | 2,4,6-Trifluorophenylboronic acid | Confirm the name matches the structure and CAS record |
| CAS number | 182482-25-3 | Use it as a primary identity cross-reference |
| Molecular formula | C6H4BF3O2 | Useful for calculations and analytical review |
| Approximate molecular weight | 175.90 g/mol | Required for molar conversion and reaction charging |
| Fluorine content by structure | 3 fluorine atoms per molecule | Relevant to medicinal chemistry and fluorine-containing intermediates |
| Functional group | Arylboronic acid | Supports cross-coupling and related synthetic applications |
| Physical form | Confirm from the current batch specification | Influences weighing, transfer, and packaging selection |
| Assay and impurities | Supplier- and batch-specific | Important for reaction performance and downstream purification |
I do not recommend treating a generic melting point, appearance description, or purity value from an unrelated listing as the specification for every batch. Boronic acids may show differences related to hydration, handling, measurement method, or storage history. For a qualified purchase, I request a current COA showing the tested assay method, residual solvents where applicable, water content where relevant, and an impurity profile appropriate to the intended use.
A practical identity package may include proton nuclear magnetic resonance, fluorine-19 nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, high-performance liquid chromatography, liquid chromatography–mass spectrometry, and elemental or water analysis where appropriate. The exact test panel should reflect the customer’s quality system rather than a fixed universal checklist. I also recommend confirming whether the reported assay is area percent, weight percent, or another defined basis.
The presence of three fluorine atoms makes fluorine-19 NMR a potentially useful orthogonal identity check, but the acceptance criteria should be established by the responsible analytical team. HPLC retention time by itself is not a complete structural confirmation. For development or regulated work, I prefer a combination of orthogonal analytical evidence and traceable batch documentation.
The most recognizable use of 2,4,6-trifluorophenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling with a suitable aryl or heteroaryl halide or related electrophile. In a typical development workflow, the boronic acid is screened with a compatible palladium catalyst, base, solvent, temperature, and reaction time. The exact conversion and selectivity depend on the coupling partner and conditions, so I do not treat the compound as a guaranteed solution for every substrate.
The reagent can be valuable when a project requires a trifluorinated aryl fragment in a biaryl or heteroaryl architecture. The three fluorine substituents may influence molecular lipophilicity, metabolic stability, conformation, and electronic properties, although the actual effect must be evaluated for the complete target molecule. These characteristics are project-dependent and should not be interpreted as a universal performance claim.
Medicinal chemistry teams may use this building block to introduce a defined fluorinated aromatic motif during analogue synthesis. It can support parallel synthesis, structure–activity relationship programs, and route exploration when the target contains a 2,4,6-trifluorophenyl group. I recommend checking the compatibility of the boronic acid with protecting groups, heterocycles, catalyst systems, and purification conditions before committing to a large quantity.
For process development, the key questions are different from those used in a discovery screen. The process team should assess charging accuracy, impurity carryover, crystallization or isolation behavior, catalyst removal, waste handling, and the reproducibility of the coupling step. A small-scale reaction that works at 50 mg may require a different base, mixing strategy, or addition sequence at a larger scale.
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Suppliers may offer this compound in different pack sizes and quality categories rather than fundamentally different chemical grades. Common purchasing options can include research-grade material, custom-synthesized batches, and larger development quantities subject to a negotiated specification. I advise buyers to compare the actual test methods and release criteria instead of relying only on labels such as “high purity” or “premium grade.”
The best option depends on the customer’s intended use, not only on the requested weight. A discovery team may prioritize rapid availability and a suitable analytical package, while a process team may prioritize lot consistency and supply continuity. I can help align the material format with the buyer’s reaction stage and quality requirements.
Start with the exact product name, CAS number, molecular formula, and structure. Confirm that the requested material is 2,4,6-trifluorophenylboronic acid rather than a positional isomer, ester derivative, or another fluorinated phenylboronic acid. This basic check prevents avoidable errors in purchasing, inventory management, and reaction calculations.
Ask whether the project requires a minimum assay, defined impurity limits, residual solvent controls, water testing, or a specific analytical method. For routine research, a standard specification may be sufficient, while process development may require additional characterization and lot-to-lot comparison. I recommend recording acceptance criteria before requesting quotations so that suppliers are evaluated on comparable terms.
Estimate the number of reactions, theoretical yield, screening conditions, and expected repeats before selecting a pack size. At a molecular weight of approximately 175.90 g/mol, the required mass can be converted directly from the planned molar charge, but excess material may be needed for optimization and repeat testing. A staged purchase can reduce inventory exposure when the synthetic route is still under evaluation.
Request the supplier’s recommended storage conditions and packaging configuration because these details are product- and batch-specific. The buyer should consider container closure, light exposure, moisture control, shipping duration, and the number of times the container will be opened. I do not assign a universal shelf life or storage temperature without a validated supplier specification.
The price of 2,4,6-trifluorophenylboronic acid generally depends on quantity, purity requirement, production route, analytical package, packaging, and delivery destination. A small research pack may have a higher price per gram than a development or production lot because fixed testing and handling costs are distributed over less material. For this reason, buyers should request tiered quotations rather than comparing one pack size in isolation.
Minimum order quantity and lead time are not universal values for this product. They may change according to available inventory, synthesis scheduling, batch size, customer-specific testing, and export documentation. I recommend requesting three pieces of information in the quotation: available stock or production status, estimated dispatch date, and the conditions that could change the delivery schedule.
For repeat programs, a supply agreement or forecast can make planning easier, but it should not replace batch release review. Buyers should also clarify whether the quoted price includes a COA, SDS, export documents, special labels, and transportation packaging. These details can materially affect the total landed cost.
Maison Chemical supports B2B buyers by discussing product identity, requested quantity, specification expectations, documentation, packaging, and delivery planning before quotation. I can provide a practical supply proposal for research quantities, development projects, or larger requirements after reviewing the customer’s target specification. Any final commercial and technical commitment should be confirmed against the current batch documentation and agreed purchase terms.
Source: The International Council for Harmonisation provides quality guidance for pharmaceutical development and manufacturing documentation through its official quality guidelines, including ICH Q7 and ICH Q9. These documents do not establish a universal specification for this compound, but they provide useful principles for supplier qualification, risk assessment, and material control: ICH Quality Guidelines.
2,4,6-Trifluorophenylboronic acid CAS 182482-25-3 is a suitable candidate for projects that require a defined trifluorinated aryl fragment, particularly in cross-coupling and medicinal chemistry workflows. The core purchasing decision should be based on verified identity, project-appropriate quality requirements, analytical documentation, and supply reliability rather than price alone. Because supplier specifications vary, I recommend treating the current COA and agreed specification as the final reference for each batch.
To begin sourcing, prepare the required quantity, target assay, intended application, packaging preference, destination, and requested delivery date. Maison Chemical can then review the requirement and discuss available material, custom supply options, documentation, MOQ, and lead time. Contact our sales team with the CAS number 182482-25-3 and your project specification to request a tailored B2B quotation.
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