3,4-Difluoro-2-methoxyphenylboronic acid, identified by CAS No. 905583-06-4, is a substituted aryl boronic acid used primarily as a synthetic building block in medicinal chemistry, pharmaceutical intermediate development, and advanced organic synthesis. Its structure combines an aryl boronic acid group with two fluorine substituents and one methoxy group. This combination can support carbon–carbon bond-forming chemistry, especially Suzuki–Miyaura coupling, although the appropriate reaction conditions must be confirmed experimentally for each substrate. At Maison Chemical, we recommend evaluating this material through verified identity, purity, analytical documentation, packaging, and supply requirements rather than relying on the chemical name alone.
3,4-Difluoro-2-methoxyphenylboronic acid is an aromatic organoboron compound. The boronic acid functional group is the reactive portion commonly used to introduce a substituted aryl fragment into a larger molecule, while the fluorine and methoxy substituents modify the electronic and steric properties of the aromatic ring. The CAS number 905583-06-4 should be used together with the chemical name, structure, and supplier documentation when requesting a quotation or placing an order.
Based on the stated substitution pattern, the calculated molecular formula is C7H7BF2O3, with a calculated molecular weight of approximately 194.00 g/mol. This calculated value should not replace the molecular-weight information shown on the supplier’s current specification sheet or certificate of analysis. Buyers should also confirm whether the offered material is an anhydrous product, a hydrate, or another documented form.
For an independent identity check, buyers can compare the supplier’s technical data with recognized chemical databases such as PubChem and the CAS Registry information. PubChem provides structure and identifier resources, but it does not replace lot-specific quality documentation from the manufacturer or distributor.
Reference: PubChem, National Center for Biotechnology Information.
The principal synthetic value of this compound is its aryl boronic acid functionality. Aryl boronic acids are commonly used with aryl or vinyl halides in palladium-catalyzed Suzuki–Miyaura reactions to form biaryl or aryl–vinyl products. The actual reaction outcome depends on catalyst selection, base, solvent, temperature, water content, concentration, and the structures of both coupling partners.
The difluoro and methoxy substituents provide a defined substitution pattern for library synthesis and analogue preparation. In pharmaceutical research, controlled substitution can help chemists explore structure–activity relationships, polarity, metabolic behavior, and binding interactions. These effects are molecule-dependent, so the presence of fluorine or methoxy groups should not be treated as a guaranteed performance advantage.
Researchers may use CAS 905583-06-4 as an intermediate or research reagent during the preparation of fluorinated aromatic compounds. Potential applications include small-molecule discovery, route scouting, process development, and the synthesis of reference compounds. Whether it is suitable for a regulated pharmaceutical manufacturing route depends on the complete quality system, impurity profile, analytical method, and documentation required by the buyer.
At early development scale, this material may be evaluated in milligram or gram quantities to establish reaction feasibility. At later stages, buyers typically need stronger control of lot consistency, residual solvents, trace metals, water content, packaging, and change notification. A successful laboratory reaction is not by itself evidence that the material is suitable for commercial manufacturing.
These scenarios describe reasonable chemical uses for an aryl boronic acid building block; they do not confirm a specific drug application or regulatory status. The end user remains responsible for evaluating reaction safety, product suitability, and legal requirements in the destination country.
When sourcing this compound, the important “type” is usually not a different chemical grade but the documented supply form and quality level. A buyer may encounter research-grade, synthesis-grade, or custom-manufactured material, but these labels are not interchangeable unless the supplier defines their acceptance criteria. The specification should state the identity, assay or purity method, appearance, water content where relevant, and impurity controls.
| Specification Item | What to Confirm | Why It Matters |
|---|---|---|
| CAS number | 905583-06-4 | Reduces the risk of ordering a positional isomer or similarly named compound. |
| Chemical formula | Expected formula: C7H7BF2O3 | Supports structure and molecular-weight verification. |
| Calculated molecular weight | Approximately 194.00 g/mol | Useful for reaction calculations and material planning. |
| Assay or purity | Buyer-defined value, such as a documented minimum percentage | Helps assess suitability for discovery or process work. |
| Identity testing | NMR, LC-MS, IR, or another validated approach | Confirms that the material matches the requested structure. |
| Water content | Report in percentage or ppm when relevant | Water can influence certain coupling reactions and storage behavior. |
| Residual solvents | Report in ppm or according to the agreed specification | Important for process development and downstream purification. |
| Packaging quantity | For example, 1 g, 10 g, 100 g, or a project-defined amount | Aligns shipment size with laboratory or manufacturing needs. |
The values above are identification and purchasing checkpoints, not a lot-specific certificate. Maison Chemical can review the required specification with the buyer before quotation so that the requested purity, testing, packaging, and documentation are clearly defined.
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Buyers should handle this material according to the current supplier safety data sheet and the requirements of their own facility. A boronic acid reagent should be kept in a properly closed container and protected from conditions that the SDS identifies as incompatible, including excessive heat, moisture, or unsuitable chemicals. The correct storage temperature must be confirmed from the product-specific SDS and stability information; buyers should not assume that a universal temperature such as 2–8°C is appropriate for every lot.
Personnel should use suitable laboratory controls, including appropriate gloves, eye protection, ventilation, labeling, and spill procedures. The SDS should be reviewed before opening the package, particularly for hazard classification, first-aid measures, transport information, and disposal requirements. For commercial projects, the buyer should also confirm whether the material requires special declarations or import documentation.
Reference: U.S. Occupational Safety and Health Administration, Hazard Communication Standard.
Start by matching the CAS number, chemical structure, formula, and molecular weight. Ask for a representative certificate of analysis or a recent batch document showing the analytical methods used. If the compound will enter a regulated or late-stage process, define acceptance criteria before the first commercial quotation.
“High purity” is not a complete specification unless the supplier states the test method and acceptance limit. Ask whether purity is measured by HPLC area percentage, assay by another method, or a combination of techniques. For cross-coupling chemistry, buyers may also need information about residual palladium, other metals, related boronic acid impurities, and residual solvents.
Confirm whether the material is available from existing inventory, produced to order, or subject to a new synthesis schedule. Request the minimum order quantity, estimated lead time, shelf-life or retest information, and packaging configuration in writing. A small research order and a kilogram-scale process order may require different production controls and release documentation.
Depending on the destination, the transaction may require an SDS, commercial invoice, packing list, certificate of origin, customs classification support, or other documents. The buyer should confirm local import requirements before shipment. Maison Chemical can discuss the documentation package required for the intended application and destination, subject to project scope and applicable regulations.
As a chemicals supplier serving pharmaceutical and research-related applications, Maison Chemical approaches this product through specification alignment rather than a one-size-fits-all offer. We can review the requested CAS number, target quantity, purity level, analytical requirements, packaging, and delivery destination before preparing a quotation. This approach helps separate a routine research purchase from a more demanding process-development requirement.
For an inquiry, provide the required quantity in grams or kilograms, target purity in percentage, intended use, preferred delivery date in days or weeks, destination country, and any documentation requirements. If the buyer has an internal specification, sharing it at the beginning can reduce clarification cycles. We recommend approving the specification and representative documentation before confirming the purchase order.
3,4-Difluoro-2-methoxyphenylboronic acid CAS 905583-06-4 is a useful substituted aryl boronic acid for research, medicinal chemistry, and pharmaceutical intermediate development when its structure and quality match the planned synthesis. The most important buying decision is not simply the lowest price; it is whether the supplier can provide the required identity, purity, analytical evidence, packaging, and delivery support. Because lot-specific data and storage requirements can vary, buyers should confirm these items before purchase.
To begin, send Maison Chemical the CAS number, required quantity, target purity, destination, delivery schedule, and documentation expectations. We can then help define a suitable purchasing specification and review the available supply route for your project. This provides a practical basis for comparing quotations and selecting material that is appropriate for the intended stage of development.
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