2-Fluoro-4-(trifluoromethyl)phenylboronic acid, CAS 503309-11-3, is an aromatic boronic acid used primarily as a building block for carbon–carbon bond formation, especially in Suzuki–Miyaura coupling research and pharmaceutical intermediate development. I recommend treating this material as a project-specific reagent rather than selecting it by CAS number alone. Before purchasing, buyers should confirm identity, assay, water content, appearance, packaging, storage conditions, and the required documentation with the supplier.
Maison Chemical supplies this specialty chemical for research, process development, and commercial sourcing evaluation. The compound is commonly represented by the molecular formula C7H5BF4O2, with a calculated molecular weight of approximately 207.92 g/mol. Because product specifications can differ by grade, batch, and intended use, I advise requesting the current specification sheet, certificate of analysis, safety data sheet, and quotation before making a purchase decision.
This guide is intended for pharmaceutical and agrochemical intermediate buyers, medicinal chemistry teams, process chemists, contract research organizations, and chemical distributors. It is also useful for procurement specialists comparing custom sourcing, laboratory quantities, and larger development requirements. The goal is to help buyers identify the material correctly, match it to an application, and evaluate supplier reliability without relying on unverified assumptions.
For routine laboratory screening, the primary concern is usually identity and handling suitability. For process development or repeat production, the buyer must also assess batch consistency, impurity control, packaging, change notification, and supply continuity. These requirements should be discussed before a purchase order is issued.
This compound contains an aromatic ring substituted with a boronic acid group, one fluorine atom, and one trifluoromethyl group. The boronic acid functionality is the key reactive group in many cross-coupling workflows, while the fluoro and trifluoromethyl substituents modify the electronic and lipophilic characteristics of the resulting molecule. These structural features make the compound relevant to the preparation of substituted biaryl and heteroaryl molecules.
The material should be distinguished from positional isomers such as 3-fluoro- or 4-fluoro-(trifluoromethyl)phenylboronic acid. Similar names can refer to different ring substitution patterns, and those isomers may have different reactivity, analytical profiles, and suitability for a target synthesis. For this reason, I recommend confirming the CAS number, structure, molecular formula, and analytical data together.
| Item | Reference information | Buyer verification point |
|---|---|---|
| Product name | 2-Fluoro-4-(trifluoromethyl)phenylboronic acid | Check spelling and positional substitution |
| CAS number | 503309-11-3 | Match the supplier’s documents and label |
| Commonly represented formula | C7H5BF4O2 | Confirm against the current product specification |
| Calculated molecular weight | Approximately 207.92 g/mol | Use the supplier’s stated value for ordering and records |
| Functional group | Aryl boronic acid | Review compatibility with the planned reaction |
The formula and molecular weight above are structural reference points, not a substitute for a batch certificate. Buyers should use the supplier’s current technical documentation when preparing formulations, regulatory files, or manufacturing instructions. If the material is intended for a regulated or quality-critical process, analytical acceptance criteria should be agreed in writing.
The most recognizable use of this aryl boronic acid is as a coupling partner in Suzuki–Miyaura reactions. In an appropriate reaction system, an aryl boronic acid can react with an aryl or heteroaryl halide in the presence of a palladium catalyst and base to form a new carbon–carbon bond. The exact yield, selectivity, catalyst system, and purification requirements depend on the reaction partners and process conditions, so I do not recommend assuming performance from the name alone.
Medicinal chemistry groups may use this building block to introduce a fluoro-trifluoromethyl-substituted aryl fragment into exploratory compounds. Pharmaceutical intermediate manufacturers may evaluate it when a target route requires a specifically substituted biaryl structure. It can also be considered for route scouting, analogue synthesis, and process chemistry when the substitution pattern is part of the target molecule’s design.
Different projects require different purchasing specifications. A discovery chemistry team may prioritize small-pack availability, rapid documentation, and a practical assay range, while a process team may require tighter impurity limits, repeatable packaging, and a defined resupply plan. A distributor may additionally need stable labeling, transport documentation, and consistent commercial packaging.
I suggest dividing requirements into three levels: mandatory identity requirements, application-specific quality requirements, and commercial requirements. Mandatory identity requirements include CAS number, structure, formula, and analytical confirmation. Application-specific requirements may include assay, water content, residual solvents, related substances, particle characteristics, or a customer-defined test method.
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A reliable supplier should be able to explain how the product is identified and what information is included in the certificate of analysis. Commonly reviewed data may include appearance, assay by an appropriate analytical method, water content, and chromatographic purity. The exact test methods and acceptance limits should be confirmed for the specific batch rather than inferred from a general catalog description.
For a technical inquiry, I recommend requesting the product specification, representative or batch-specific certificate of analysis, safety data sheet, and packaging details. If the material will enter a controlled development or manufacturing route, ask whether the supplier can support a quality agreement, change communication, traceability, and additional analytical testing. These points are more useful than relying on a single headline purity number.
Buyers should follow the supplier’s current safety data sheet and label for storage and handling. Boronic acids can be sensitive to moisture or changes in storage conditions depending on their structure and formulation, so packaging integrity and exposure control should be evaluated during receiving and use. Do not assign a fixed shelf life or storage temperature unless those values are supported by the supplier’s documentation.
Packaging should match the purchase scale and the intended frequency of opening. For laboratory use, smaller sealed containers may reduce repeated exposure, while development or production programs may require larger, appropriately protected packaging. Ask Maison Chemical to confirm available pack sizes, outer packaging, labeling, and shipping conditions for the destination country.
The cost of this type of specialty intermediate may depend on quantity, grade, analytical requirements, packaging, destination, and whether the material is supplied from existing stock or arranged through a production schedule. A low unit price is not necessarily the lowest total procurement cost if documentation, testing, or delivery reliability is inadequate. I recommend comparing complete quotations using the same specification and delivery terms.
Minimum order quantity and lead time should be quoted specifically for the required grade. For a first inquiry, provide the requested quantity, target delivery location, application stage, required documents, and any acceptance criteria. This allows Maison Chemical to distinguish a laboratory request from a development or commercial sourcing project and respond with more relevant supply information.
Maison Chemical supports B2B buyers by discussing product identification, documentation needs, quantity planning, and delivery requirements before quotation. As a manufacturer, supplier, and exporter of pharmaceutical intermediates and specialty chemicals, we can review whether the requested specification is suitable for the buyer’s intended stage. Any final quality commitment should be based on the agreed commercial specification and the documentation supplied for the relevant batch.
The most common purchasing mistake is ordering a similarly named positional isomer without checking the CAS number and structure. Another mistake is requesting only a price while omitting the required purity, analytical method, packaging, and destination. These omissions can create avoidable differences between the material quoted and the material required by the laboratory or production process.
A better approach is to send a concise technical inquiry that includes the CAS number, target quantity, intended application, required assay or purity, documentation list, delivery location, and desired timing. If the product is for a regulated development program, also include any special impurity, residual solvent, elemental impurity, or change-control expectations. The supplier can then confirm feasibility rather than providing a generic catalog response.
2-Fluoro-4-(trifluoromethyl)phenylboronic acid CAS 503309-11-3 can be a useful synthetic intermediate when the target route requires this exact substitution pattern. The right purchasing decision depends on verified identity, application-appropriate quality data, and a supplier capable of supporting the required quantity and documentation. I recommend confirming these points before comparing price or approving a vendor.
To request a quotation from Maison Chemical, send the required quantity, destination, intended use, target specification, packaging preference, and documentation requirements. We can then review the inquiry, confirm available supply options, and provide a practical B2B response for your project stage. This process helps ensure that the material selected is chemically appropriate, commercially workable, and properly documented.
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