1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester, identified by CAS No. 903550-26-5, is a boronic ester building block used primarily in synthetic chemistry and pharmaceutical intermediate development. Its structure combines a pyrazole ring, a tetrahydropyranyl protecting group, and a pinacol boronate functionality suitable for palladium-catalyzed cross-coupling research. I supply this compound through Maison Chemical with procurement support focused on identity confirmation, documentation, packaging, and project-based delivery. Because exact purity, appearance, analytical data, and stock status can vary by batch, buyers should confirm the current specification before placing an order.
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This compound is an organoboron intermediate rather than a finished active pharmaceutical ingredient. The boronic acid pinacol ester group is commonly used as a protected boron functionality in carbon-carbon bond-forming reactions, while the tetrahydropyranyl group can help control the reactivity of the pyrazole nitrogen during synthesis. The material is commonly listed with the molecular formula C15H23BN2O3 and a molecular weight of approximately 290.17 g/mol.
For purchasing and quality review, the CAS number should be used together with the chemical name, molecular formula, molecular weight, and supplier documentation. Names can appear in different formats, including “1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester.” These names may refer to the same intended structure, but I recommend confirming the structure and analytical identifiers before using the material in a regulated or scale-up process.
The principal synthetic role of this material is to provide a protected boronate group for cross-coupling development. In suitable reaction systems, an organoboron reagent can participate in carbon-carbon bond formation with an appropriate aryl, heteroaryl, or vinyl electrophile. The actual reaction outcome depends on the catalyst, base, solvent, temperature, substrate compatibility, and work-up procedure, so the compound should not be treated as a universal coupling reagent.
The pyrazole ring is a useful heteroaromatic motif in medicinal chemistry and advanced intermediate synthesis. Tetrahydropyranyl protection on the pyrazole nitrogen may help manage selectivity during multi-step synthesis, but the protection and deprotection conditions must be evaluated for each route. I recommend confirming compatibility with the customer’s downstream chemistry rather than assuming that standard conditions will apply unchanged.
These are potential uses based on the compound’s functional groups and are not claims that the material is approved for a particular pharmaceutical product. Final application suitability must be established through the buyer’s own reaction screening, analytical testing, safety review, and regulatory assessment.
For this product, the most important “option” is usually not a different chemical grade but a different supply format and documentation package. A research buyer may request a small evaluation quantity, while a process-development team may need repeatable batches, controlled packaging, and expanded analytical information. Maison Chemical can discuss the required quantity, target application, destination country, and documentation needs before confirming a quotation.
Buyers may also need to distinguish between a standard research-grade supply and a customized project supply. A customized request can include a defined analytical testing package, specific packaging, batch reservation, or a manufacturing schedule. Such arrangements should be confirmed individually because available options depend on production planning, raw material access, quality requirements, and export conditions.
| Item | What to Confirm | Why It Matters |
|---|---|---|
| Identity | CAS No. 903550-26-5, chemical name, structure, and formula | Prevents confusion with related pyrazole or boronate intermediates |
| Assay or purity | Current batch specification and analytical method | Supports reaction planning and material qualification |
| Analytical data | Available HPLC, NMR, LC-MS, water, and residual-solvent data | Helps the technical team assess batch suitability |
| Physical form | Appearance, solid form, and packaging condition | Supports handling, weighing, and laboratory procedures |
| Documentation | Certificate of Analysis, SDS, and shipping documents where applicable | Facilitates internal approval and international procurement |
The molecular weight of approximately 290.17 g/mol is useful for calculating reaction quantities and molar equivalents. However, molecular weight alone does not confirm purity or identity. For a qualified purchase, I recommend requesting the batch-specific Certificate of Analysis rather than relying only on a catalog description.
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As an organoboron heterocyclic intermediate, this material should be handled by trained personnel in accordance with the supplier’s SDS and the buyer’s laboratory procedures. Avoid exposure to moisture, heat, incompatible chemicals, and unnecessary air contact when the product documentation indicates that these factors may affect stability. The exact storage temperature and shelf-life should be taken from the current batch documentation rather than assumed from the chemical name.
For an initial reaction screen, a buyer may plan a small test quantity such as 10–100 mg, depending on the reaction scale and analytical method. This is a planning range, not a certified usage limit or a recommended production condition. Before scale-up, the research team should evaluate material balance, reaction conversion, impurity behavior, isolation performance, and the stability of both the starting material and the resulting intermediate.
A suitable supplier should be able to connect the product identity with a specific batch and provide clear commercial information. I suggest checking whether the supplier can answer questions about current availability, lead time, packaging, documentation, and export handling. A low quoted price is less useful if the material cannot be supported with appropriate analytical records or delivered within the project schedule.
Before requesting a quotation, provide the required quantity, target delivery location, intended use, preferred packaging, and documentation requirements. If the compound is for process development, also explain whether repeat batches or a larger future quantity may be required. Early communication helps Maison Chemical assess whether a standard supply or a project-specific arrangement is more appropriate.
At Maison Chemical, I support buyers looking for 1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester CAS 903550-26-5 for research, intermediate development, and international sourcing. Our role is to clarify the requested specification, coordinate batch and documentation information, and provide a practical quotation based on quantity and destination. We do not replace the customer’s technical qualification process, but we aim to make that process more efficient and transparent.
For repeat projects, buyers can discuss forecast quantities, preferred delivery schedules, packaging formats, and quality-document needs in advance. Lead time and minimum order quantity are project-dependent and should be confirmed at the quotation stage. We also recommend that customers review the SDS, import requirements, and internal approval procedures before dispatch.
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester CAS 903550-26-5 is a specialized organoboron intermediate designed for synthetic research rather than direct pharmaceutical use. Its protected boronate and pyrazole functionalities make it a practical candidate for cross-coupling and advanced heterocyclic synthesis, subject to route-specific validation. The most reliable purchasing decision comes from matching the compound’s identity and batch data with the buyer’s reaction, quality, and delivery requirements.
To begin, send Maison Chemical the required quantity, destination country, intended application, and documentation expectations. I can then help confirm the available specification, commercial terms, packaging, and estimated lead time. This information allows your procurement and technical teams to evaluate the material before placing an order.
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