3,4,5-Trifluorophenylboronic acid, CAS 143418-49-9, is a fluorinated aryl boronic acid used primarily as a building block in organic synthesis, especially palladium-catalyzed Suzuki–Miyaura coupling. Its key identifying information includes the molecular formula C6H4BF3O2 and a calculated molecular weight of approximately 175.90 g/mol. At Maison Chemical, we support buyers by confirming identity, quality requirements, packaging, documentation, and shipping conditions before quotation.
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This product is generally selected when a project requires a 3,4,5-trifluorophenyl group to be introduced into a more complex molecule. Because commercial specifications, analytical results, packaging, and lead times can vary by production batch and order quantity, buyers should evaluate the current certificate of analysis rather than rely only on a catalog description. The most reliable purchasing process begins with a defined specification and a documented application need.
This guide is intended for medicinal chemistry teams, pharmaceutical and agrochemical intermediate manufacturers, research organizations, process development groups, and chemical distributors sourcing 3,4,5-trifluorophenylboronic acid. It is also useful for procurement specialists who need to compare suppliers beyond unit price. I focus here on practical buying questions: what the material is, where it may fit, which specifications matter, and what information should be requested before placing an order.
The guide is not a substitute for a project-specific risk assessment, process validation, or the supplier’s Safety Data Sheet. Reaction performance depends on the substrate, catalyst system, solvent, base, water content, temperature, and work-up procedure. For that reason, I recommend treating this material as a defined synthetic reagent rather than assuming that one grade will perform identically in every reaction.
3,4,5-Trifluorophenylboronic acid contains an aryl boronic acid functional group and three fluorine substituents on the aromatic ring. The boronic acid group is valuable because it can participate in carbon–carbon bond-forming reactions, while fluorine substitution can alter the electronic and lipophilic properties of the resulting molecule. These combined features make the compound relevant to the preparation of fluorinated research intermediates.
The principal synthetic use is as an aryl donor in Suzuki–Miyaura coupling with a suitable aryl or vinyl halide, pseudohalide, or related electrophile under an appropriate reaction system. The exact reaction conditions must be developed for the target substrate, and I do not recommend presenting any single catalyst, solvent, or temperature as universally applicable. Buyers should request technical guidance and review the available batch documentation when the compound will be used in a regulated or scale-sensitive process.
The identity of the product should be confirmed using the stated CAS number, chemical name, molecular formula, and molecular weight. For 3,4,5-trifluorophenylboronic acid, the commonly referenced formula is C6H4BF3O2, with a molecular weight of approximately 175.90 g/mol. These values are useful for checking purchasing records, inventory systems, reaction calculations, and import documents.
| Specification area | What to confirm before purchase |
|---|---|
| Identity | CAS 143418-49-9, chemical name, formula, and molecular weight |
| Assay or purity | Target purity, analytical method, reporting basis, and batch result |
| Impurity profile | Relevant organic impurities, residual solvents, inorganic residues, and water where applicable |
| Physical form | Current batch description, color, particle form, and any special handling notes |
| Packaging | Container type, net weight, labeling, sealing, and protection from unsuitable storage conditions |
| Documentation | Certificate of analysis, Safety Data Sheet, specification sheet, and shipping documents as required |
Purity is important, but it should not be evaluated in isolation. A buyer may need a particular impurity limit, water specification, residual solvent profile, or analytical method depending on the downstream reaction and quality system. I recommend asking for a representative COA and confirming whether the reported result is based on HPLC, NMR, titration, or another stated method before comparing suppliers.
The most direct application is the synthesis of biaryl and related fluorinated aromatic compounds through cross-coupling. These products may serve as research intermediates in medicinal chemistry, pharmaceutical discovery, agrochemical development, and specialty organic synthesis. The compound may also be used in route scouting, analog generation, and structure–activity relationship studies where a trifluorinated aromatic motif is required.
Fluorinated aromatic fragments are frequently explored during molecular design because fluorine substitution can influence molecular properties and biological activity. However, the presence of a trifluorophenyl group does not guarantee a particular pharmacological outcome. Its value is project-specific, so development teams should evaluate the complete target structure, reaction compatibility, purification profile, and downstream analytical requirements.
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For process teams, the key questions are reproducibility, impurity control, availability, and scale-appropriate packaging. A small research pack may be sufficient for route screening, while production planning requires a more detailed review of batch consistency, supply continuity, transport classification, and quality documentation. I recommend testing a representative batch before committing the material to a larger campaign.
Handling should follow the current Safety Data Sheet and the requirements of the user’s site. Personnel should use suitable laboratory or plant controls, including appropriate protective equipment, containment, ventilation, and procedures for accidental release. Because the exact physical and stability characteristics can depend on the material form and packaging, storage temperature and moisture-protection requirements should be confirmed with the supplier rather than assumed.
For procurement and quality review, the usual documentation package may include a COA, SDS, product specification, invoice or packing list, and transport documentation where applicable. Some projects may also require a statement regarding residual solvents, elemental impurities, allergen status, animal-origin materials, or regulatory declarations. Maison Chemical can review the buyer’s documentation checklist before quotation so that avoidable gaps are identified early.
A suitable supplier should be able to identify the product unambiguously, explain the offered grade, and provide batch-relevant documentation. I advise buyers to compare the actual specification and service scope rather than comparing only price per kilogram. A lower quoted price may not represent better value if the documentation, packaging, lead time, or impurity control does not match the project.
MOQ and lead time are normally quotation-dependent because they can be affected by available inventory, production scheduling, packaging format, testing requirements, and destination. I do not recommend assuming that a catalog quantity or standard delivery period applies to every order. Instead, provide the intended quantity, destination, required delivery date, and specification so the supplier can issue a realistic offer.
Maison Chemical supplies organic boronic acid products for research, development, and industrial sourcing requirements. Our role is to help buyers connect the chemical identity with the practical requirements of their project, including grade selection, documentation, packaging, and export coordination. We use a quotation-based process so that the requested quantity and quality criteria can be reviewed before commercial confirmation.
For a more useful evaluation, send us the CAS number, target quantity, preferred purity, application stage, destination country, and any required documents. If you are still in route-screening, a smaller evaluation quantity and representative analytical documentation may be appropriate. If you are planning scale-up, we can discuss batch planning, packaging options, testing expectations, and supply continuity based on the order scope.
3,4,5-Trifluorophenylboronic acid CAS 143418-49-9 is a relevant choice when your synthesis requires a 3,4,5-trifluorophenyl building block, but the right purchase depends on more than chemical identity. Start by defining the required purity, analytical method, quantity, packaging, and documentation. Then compare suppliers based on specification fit, batch evidence, delivery practicality, and technical responsiveness.
As a next step, contact Maison Chemical with your target quantity, destination, desired specification, and application stage. We can review the requirement, confirm current availability, provide applicable documentation, and prepare a quotation for your evaluation. This approach helps you move from a generic catalog search to a documented sourcing decision that is better aligned with laboratory, development, or manufacturing needs.
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