4-Hydroxycyclohexanone ethylene acetal, identified by CAS 22428-87-1, is a protected cyclohexanone derivative used mainly as a specialty intermediate in organic synthesis. Its molecular formula is commonly represented as C8H14O2, with a calculated molecular weight of approximately 142.20 g/mol. The ethylene acetal protects the ketone functionality, while the hydroxyl group remains available for further chemical transformation. At Maison Chemical, I position this material for buyers who need a defined building block, dependable documentation, and practical support for laboratory, process-development, or manufacturing programs.
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In simple terms, this compound is a cyclohexane-based molecule containing a hydroxyl group and an acetal-protected ketone. The ketone is converted into an ethylene acetal, also called an ethylene ketal, by incorporating an ethylene glycol-derived cyclic acetal unit. This protection can help chemists carry out selected reactions at other functional sites before regenerating the ketone under suitable hydrolysis conditions.
The CAS number 22428-87-1 is the primary identity reference buyers should use when requesting quotations, samples, safety documents, or analytical records. Because chemical names can vary between suppliers and databases, I recommend confirming the CAS number together with the molecular formula, structure, and analytical specification. This basic identity check reduces the risk of comparing a related cyclohexanone derivative rather than the intended product.
The molecule contains two important functional features: a secondary alcohol and a cyclic acetal. The alcohol can participate in derivatization, oxidation, esterification, etherification, or other transformations depending on the reaction design. The acetal is generally treated as a protected carbonyl equivalent, although its stability depends on the reaction medium and operating conditions.
This combination makes the compound useful when a synthetic route requires controlled reactivity. I would not describe it as a general-purpose solvent, formulation additive, or finished pharmaceutical ingredient. Its value is primarily as a carefully selected intermediate for multi-step synthesis.
For purchasing and process planning, the most important starting data are the compound identity and composition. The commonly cited formula is C8H14O2, and its approximate molecular weight is 142.20 g/mol. Buyers should still use the supplier’s current specification and certificate of analysis for release decisions, because appearance, purity, water content, residual solvents, and analytical methods may vary by grade and production batch.
| Item | Reference information | Buyer relevance |
|---|---|---|
| CAS number | 22428-87-1 | Primary identity check for sourcing and documentation |
| Molecular formula | C8H14O2 | Useful for reaction calculations and database verification |
| Approximate molecular weight | 142.20 g/mol | Used for molar conversions, stoichiometry, and procurement planning |
| Functional description | Hydroxy-substituted cyclic ethylene acetal | Helps assess compatibility with the intended synthetic route |
Publicly available product data may not consistently report a single physical form, melting range, boiling point, or storage temperature for every commercial grade. For that reason, I recommend treating appearance and handling conditions as specification-dependent rather than assuming that one published value applies to every batch. The current SDS, technical data sheet, and certificate of analysis should control laboratory and plant handling decisions.
One important use is as a building block in pharmaceutical and medicinal chemistry research. The protected ketone can be carried through reactions where an unprotected cyclohexanone might undergo unwanted side reactions. The hydroxyl group offers another point for selective modification, enabling route designers to introduce substituents or connect the intermediate with other fragments.
I recommend evaluating this material at the route-development stage by checking acetal stability, alcohol reactivity, and the planned deprotection conditions. The best application is not determined by the name alone; it depends on the complete reaction sequence, reagent compatibility, and purification strategy. A small-scale feasibility experiment is appropriate before committing to larger production volumes.
Research organizations may use 4-Hydroxycyclohexanone ethylene acetal in reaction screening, medicinal chemistry libraries, and process-development studies. It can serve as a protected intermediate when chemists need to differentiate the carbonyl-derived site from the hydroxyl-bearing position. In a process setting, the selection should also consider impurity profiles, isolation behavior, solvent use, and the practicality of removing the protecting group later.
The compound may also be considered for the preparation of more complex cyclohexane derivatives. However, I avoid presenting a single reaction pathway as universally suitable because yield, selectivity, and work-up requirements depend on the specific reagents and conditions used by each development team.
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Buyers may encounter different supply formats rather than fundamentally different chemical identities. Typical distinctions include research-scale material, development or pilot quantities, and production-oriented batches. The relevant differences may involve packaging, minimum order quantity, analytical documentation, batch size, and lead time rather than a change in the core CAS identity.
When requesting a quotation, I suggest specifying whether you need a sample, a small pack, or a kilogram-scale quantity. For example, a project may begin with a 1 g or 10 g evaluation sample and later move to kilogram purchasing after the synthetic route is confirmed. These quantities are planning examples, not a guarantee of available stock, so Maison Chemical should confirm current packaging and supply status before the order is placed.
First, verify that the quotation, label, SDS, and certificate of analysis all refer to CAS 22428-87-1. Ask which analytical techniques are used for release testing, such as chromatography, nuclear magnetic resonance, or water analysis, and confirm that the reported results match your internal acceptance criteria. If your process is sensitive to trace impurities, request a discussion of the typical impurity profile before approving the source.
A research reaction may require a different specification from a regulated development program or a scale-up process. I recommend defining the required purity, water limit, residual solvent expectations, appearance, and retest policy before comparing supplier prices. The lowest quoted price is not necessarily the lowest total cost if inconsistent material creates additional purification or analytical work.
Packaging should be suitable for the ordered quantity and compatible with the supplier’s recommended storage conditions. Buyers should review the SDS for hazard classification, personal protective equipment, spill response, and transport information rather than relying only on a product webpage. If the project involves international shipping, confirm documentation requirements, labeling, customs information, and net mass in kg before dispatch.
As with other specialty organic intermediates, this material should be handled by trained personnel using the applicable laboratory or industrial controls. I recommend avoiding exposure to unnecessary heat, moisture, ignition sources, and incompatible reagents until the supplier’s SDS has been reviewed. The acetal functionality may be sensitive to acidic conditions, so compatibility should be assessed against the actual process environment.
Do not infer that a compound is safe simply because it is supplied as a research chemical or intermediate. The SDS, internal risk assessment, local regulations, and site-specific operating procedures should determine handling requirements. Maison Chemical can support document review and technical clarification, but the buyer remains responsible for confirming suitability in its own process.
At Maison Chemical, I support B2B buyers by focusing on practical sourcing information rather than unsupported performance claims. Our supply discussions can cover product identity, available grade, specification requirements, packaging, sample evaluation, documentation, and the expected quantity for the project. This approach helps procurement teams, research chemists, and pharmaceutical-intermediate manufacturers assess the material against their actual requirements.
Before issuing a purchase order, I recommend sharing the target quantity, destination country, required documents, intended application, and preferred delivery schedule. We can then confirm whether the requested specification and packaging are available and identify any information that needs technical review. Lead time and minimum order quantity should be confirmed for each quotation because they can depend on inventory, batch planning, and export arrangements.
4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is a hydroxy-substituted cyclohexanone derivative in which the ketone is protected as an ethylene acetal. Its commonly cited formula is C8H14O2, and its approximate molecular weight is 142.20 g/mol. Its principal value is as a specialty intermediate for pharmaceutical research, medicinal chemistry, and broader organic synthesis where controlled functional-group reactivity is required.
If you are evaluating this material, begin by confirming CAS 22428-87-1, formula, purity requirements, analytical documentation, packaging, and SDS information. Then request a quotation based on your actual sample, development, or production quantity rather than relying on a generic price assumption. Contact Maison Chemical with your target specification and delivery requirements so I can help you assess supply suitability and the next procurement step.
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