3-Fluorophenylboronic acid, identified by CAS 768-35-4, is an aromatic boronic acid used mainly as a building block in organic synthesis. Its molecular formula is C6H6BFO2, and its molecular weight is approximately 139.92 g/mol. I supply this compound for research, process-development, and commercial synthesis programs where a fluorinated aryl boronic acid is required for carbon–carbon bond formation, especially Suzuki–Miyaura coupling.
The compound combines a boronic acid functional group with a fluorine-substituted phenyl ring. This structure gives synthetic chemists two useful features: the boronic acid can participate in palladium-catalyzed cross-coupling, while the fluorine atom can influence the electronic and physicochemical properties of the resulting molecule. At Maison Chemical, we support buyers by confirming identity, quality requirements, packaging, and supply conditions before an order is finalized.
3-Fluorophenylboronic acid is also described as (3-fluorophenyl)boronic acid or meta-fluorophenylboronic acid. The “3-fluoro” designation means that the fluorine substituent is positioned at the meta location relative to the boronic acid group on the benzene ring. This positional arrangement is important because the location of fluorine affects molecular geometry, reaction behavior, and the properties of the final coupled product.
| Property | Information |
|---|---|
| Product name | 3-Fluorophenylboronic acid |
| CAS number | 768-35-4 |
| Molecular formula | C6H6BFO2 |
| Molecular weight | Approximately 139.92 g/mol |
| Functional groups | Aryl boronic acid and aryl fluorine |
| Physical form | Usually handled as a solid chemical intermediate; exact appearance should be confirmed by the current specification |
As with other boronic acids, this material should be evaluated using the buyer’s required analytical package rather than appearance alone. Typical identity and quality checks may include nuclear magnetic resonance spectroscopy, high-performance liquid chromatography, liquid chromatography–mass spectrometry, water content, and residual solvent analysis. The exact test methods and acceptance limits should be agreed before production or shipment.
The principal function of 3-fluorophenylboronic acid is to provide a 3-fluorophenyl group in palladium-catalyzed Suzuki–Miyaura coupling. In a typical reaction, the boronic acid reacts with an aryl or heteroaryl halide under suitable catalytic and basic conditions to form a new carbon–carbon bond. The boronic acid group is therefore not normally retained in the final product; it acts as a transferable aryl component.
Reaction performance depends on the coupling partner, catalyst system, base, solvent, temperature, concentration, and water content. I do not recommend treating one published procedure as universally applicable because optimization may be required for each substrate. Buyers should confirm whether their process requires a free boronic acid, a protected boronate ester, or a specific particle and purity profile.
The fluorine substituent provides a route to introduce fluorine into pharmaceutical, agrochemical, materials, and specialty-intermediate structures. Fluorine can alter the electronic character, lipophilicity, metabolic behavior, and stability of a molecule, but the actual effect must be assessed for the complete target structure. The value of this reagent is therefore closely linked to the design requirements of the downstream product.
Research laboratories use 3-fluorophenylboronic acid when preparing small molecules that contain a meta-fluorinated biaryl or heteroaryl–aryl motif. It may be selected for medicinal chemistry libraries, process research, reference-standard preparation, and route scouting. In these applications, consistency of identity and purity is important because small variations can affect reaction screening and analytical interpretation.
Process-development teams may also use the material when evaluating a scalable coupling route. At larger scale, the selection criteria usually expand beyond chemical purity to include lot-to-lot consistency, packaging suitability, documentation, transport classification, and the supplier’s ability to support repeat orders. A material that works in a small screening reaction may still require additional evaluation before being adopted for manufacturing.
The most important material option is usually the grade and specification, rather than a different chemical identity. A buyer may need research-grade material for exploratory work or a tighter, documented specification for process development. If the compound is intended for a regulated or quality-controlled workflow, the required documentation should be defined before purchase.
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For routine sourcing, I recommend reviewing at least the assay method, assay limit, impurity profile, water content, residual solvents, appearance, packaging, and retest or expiry information where applicable. The buyer should also confirm whether the specification is based on area percent, weight percent, or another analytical basis. These details can prevent misunderstandings when comparing quotations from different suppliers.
3-Fluorophenylboronic acid should be handled according to the supplier’s current safety data sheet and the buyer’s internal chemical-control procedures. Personnel should use suitable protective equipment, avoid unnecessary dust generation, and work with appropriate ventilation. The compound should not be treated as harmless simply because it is used as a synthesis intermediate.
For storage, buyers should keep the container tightly closed and protect the material from conditions that could compromise quality, including excess moisture, heat, and contamination. The exact storage temperature and shelf-life statement should be taken from the product-specific documentation supplied with the batch. I recommend that customers establish a receiving inspection procedure before the first shipment.
Begin by checking that the supplier is quoting 3-fluorophenylboronic acid with CAS 768-35-4, not a positional isomer or a related boronate ester. The product name, CAS number, molecular formula, and molecular weight should be consistent across the quotation, specification, label, and analytical certificate. This basic document review is especially important when several fluorophenylboronic acids are being evaluated at the same time.
Do not automatically purchase the highest stated purity without considering the reaction and process requirements. For early discovery work, a documented research specification may be sufficient, while scale-up programs may require tighter controls on specific impurities, metals, water, and residual solvents. We can discuss the intended application so that the requested specification is technically relevant rather than unnecessarily restrictive.
A suitable B2B supplier should be able to explain packaging options, batch documentation, production or procurement lead time, and the process for handling repeat orders. Buyers should also ask whether the quoted material is available from existing stock or will be scheduled for production. Lead times and minimum order quantities can change according to quantity, packaging, quality requirements, and destination, so I provide these details on a project-specific basis rather than making unsupported universal promises.
At Maison Chemical, we focus on supplying organic boronic acids and related chemical intermediates for professional buyers. We can help customers review the target identity, required purity, analytical documentation, packaging format, and intended delivery quantity before quotation. Our role is to connect the technical requirement with a practical sourcing plan.
For an initial inquiry, please provide the required quantity, target specification, delivery location, preferred packaging, and whether a sample or supporting documentation is needed. If your project is moving from laboratory screening to process development, tell us that stage as well, because the appropriate quality and documentation package may differ. We can then confirm availability, commercial terms, and the applicable batch information.
3-Fluorophenylboronic acid CAS 768-35-4 is a practical choice when your synthesis requires a meta-fluorinated aryl fragment that can be transferred through cross-coupling chemistry. Its suitability depends on the target structure, reaction route, required purity, and scale of use rather than on the chemical name alone. I recommend confirming the identity and specification first, then evaluating analytical documentation, packaging, supply timing, and repeat-order support.
Maison Chemical can support the next step by reviewing your quantity, specification, and application requirements for a suitable quotation. Send us the requested grade, delivery destination, and documentation needs, and we will help clarify the available supply route for your 3-Fluorophenylboronic acid project.
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