3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is an aromatic boronic acid intermediate containing both a boronic acid group and a hydroxymethyl group on a benzene ring. Its commonly referenced molecular formula is C7H9BO3, with a calculated molecular weight of approximately 151.96 g/mol. I recommend evaluating this material by identity, assay, water content, physical form, packaging, documentation, and intended synthetic use rather than selecting a supplier on price alone.
This guide is intended for pharmaceutical and fine chemical companies, medicinal chemistry teams, process development laboratories, contract manufacturers, and purchasing professionals sourcing 3-(Hydroxymethyl)phenylboronic acid. It is useful when the compound will serve as a building block, coupling partner, or research intermediate. I also address supplier qualification factors because commercial suitability depends on more than the CAS number.
Product requirements can differ significantly between early-stage discovery and commercial process development. A research group may need a small quantity with a certificate of analysis, while a manufacturing customer may require repeatable batches, defined specifications, change-control communication, and scalable packaging. The correct procurement decision should therefore connect the material specification with the next reaction step and the required project stage.
3-(Hydroxymethyl)phenylboronic acid is a substituted arylboronic acid. The boronic acid functionality can participate in palladium-catalyzed Suzuki-Miyaura coupling reactions with suitable aryl or heteroaryl halides, while the hydroxymethyl group provides an additional functional handle for downstream transformation or molecular diversification.
| Property | Reference information |
|---|---|
| Product name | 3-(Hydroxymethyl)phenylboronic acid |
| CAS Registry Number | 87199-15-3 |
| Molecular formula | C7H9BO3 |
| Approximate molecular weight | 151.96 g/mol |
| Key functional groups | Arylboronic acid and primary alcohol |
The compound should be regarded as a reactive, moisture-sensitive or moisture-affected boronic acid material unless the supplier’s handling data indicate otherwise. Boronic acids may undergo dehydration, oxidation, or changes in physical form during storage and processing, depending on environmental exposure and formulation. For this reason, I recommend confirming appearance, assay method, water content, and storage instructions from the current batch documentation.
The most straightforward option is the neat solid supplied in a sealed container. This format is generally suitable for laboratories and manufacturers that have established weighing, sampling, and reaction procedures. Buyers should confirm whether the material is supplied as a free-flowing powder, crystalline solid, or another physical form because physical handling can affect dispensing and sampling.
Research-grade material may be appropriate for route scouting, screening, and small-scale synthesis when the customer can verify the batch before use. Process-oriented supply normally requires more detailed discussion of impurity profiles, analytical methods, batch consistency, packaging, and repeat-order planning. These are commercial supply categories rather than universal regulatory definitions, so I recommend requesting the actual specification instead of relying on a grade name alone.
Packaging may be selected according to quantity, shipping conditions, frequency of use, and the customer’s internal controls. Small laboratory quantities can reduce initial commitment, while larger planned orders may improve supply continuity when the material is approved for a defined route. Maison Chemical can discuss quantity, packaging, documentation, and delivery expectations according to the customer’s project requirements.
The principal synthetic value of 3-(Hydroxymethyl)phenylboronic acid is the combination of two useful reaction handles in one molecule. The arylboronic acid group can be used for carbon-carbon bond formation in suitable cross-coupling chemistry, while the hydroxymethyl group can be retained, protected, oxidized, esterified, or converted into another functional group depending on the route. Actual reaction performance depends on catalyst, base, solvent, substrate, temperature, and work-up conditions.
I do not recommend assuming that every listed application is validated for a specific active pharmaceutical ingredient. The compound’s suitability must be confirmed through reaction development, impurity assessment, and project-specific analytical work. A supplier can support material selection, but the customer remains responsible for confirming process fitness and regulatory acceptability.
Start by verifying the product name, CAS number, molecular formula, molecular weight, and structural position of the substituents. Meta substitution is important because positional isomers can have different reactivity, physical properties, and analytical behavior. I recommend checking the supplier’s certificate of analysis and, where appropriate, reviewing chromatographic or spectroscopic identity data.
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Assay alone may not describe all risks in a coupling reaction. Buyers should consider water content, residual solvents, inorganic residues, related substances, physical form, and the analytical method used for release. If the compound will enter a regulated or late-stage process, the requested specification should be agreed before purchase rather than changed after delivery.
Boronic acid materials should be protected from unsuitable environmental exposure and handled according to the supplier’s safety and storage guidance. Confirm container closure, label information, recommended storage conditions, retest or review dates, and transport controls where relevant. If a project uses only 100 mg per experiment, a 1 g package represents approximately 6.58 mmol based on the molecular weight of 151.96 g/mol, so package size should be aligned with consumption and stability planning.
Ask whether the supplier can provide repeat batches, pre-shipment documentation, and a realistic lead-time estimate. A low initial quotation may not be advantageous if the material later requires requalification or if the supplier cannot support the next project stage. For manufacturing programs, I recommend discussing forecast quantities, minimum order quantity, batch size, and communication procedures for specification or manufacturing changes.
Pricing for 3-(Hydroxymethyl)phenylboronic acid generally depends on requested quantity, specification, packaging, analytical requirements, manufacturing route, and delivery destination. A laboratory sample and a repeat commercial order should not be expected to have the same unit economics. The most useful quotation request includes target quantity, desired purity or specification, destination, required documents, and expected repeat frequency.
Minimum order quantity is often influenced by available inventory and whether production is made to stock or scheduled against demand. Lead time should be confirmed for the exact quantity and specification rather than inferred from a catalog listing. I advise buyers to request both an immediate availability statement and a replenishment estimate when the material is important to a continuing synthesis program.
When I evaluate a potential supplier, I look for transparent product identification, a clear specification, consistent analytical documentation, responsive technical communication, and a practical approach to packaging and delivery. The supplier should be able to explain what is included in the certificate of analysis and which tests are performed for each batch. Claims about certification, regulatory status, or validation should be supported by documents applicable to the specific product and manufacturing arrangement.
At Maison Chemical, I approach 3-(Hydroxymethyl)phenylboronic acid as a B2B pharmaceutical intermediate and fine chemical sourcing requirement rather than as a one-size-fits-all catalog item. We can discuss the intended application, target quantity, documentation needs, packaging preferences, and delivery schedule before preparing a quotation. This helps align the offered material with the customer’s development or procurement stage.
Our support can include product identification review, specification communication, certificate of analysis coordination, quantity planning, and shipment preparation. When a customer is progressing from laboratory work toward repeat production, I recommend establishing a forecast and reviewing whether the same quality requirements can be maintained across future batches. Availability, lead time, and documentation should always be confirmed for the specific order.
3-(Hydroxymethyl)phenylboronic acid CAS 87199-15-3 is a bifunctional aromatic intermediate with an arylboronic acid group for suitable coupling chemistry and a hydroxymethyl group for further derivatization. Its commonly referenced formula is C7H9BO3, and its approximate molecular weight is 151.96 g/mol. The best supplier decision depends on verified identity, fit-for-purpose specifications, handling controls, documentation, and supply continuity.
Before placing an order, send Maison Chemical your required quantity, target specification, application stage, destination, packaging preference, and documentation requirements. We can then confirm availability, MOQ, lead time, commercial terms, and the applicable product documents. This structured approach gives your team a clearer basis for approving the material and planning the next synthesis step.
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